has material basis in developmental and epileptic encephalopathy 85 MIM:301044 A developmental and epileptic encephalopathy characterized by onset of severe refractory seizures in the first year of life, global developmental delay with impaired intellectual development and poor or absent speech, and dysmorphic facial features that has_material_basis_in heterozygous mutation in the SMC1A gene on chromosome Xp11. disease_ontology DEE85 DOID:0070380 early infantile epileptic encephalopathy 85 X-linked dominant disease developmental and epileptic encephalopathy X-linked dominant inheritance