has material basis in autosomal recessive disease mitochondrial complex IV deficiency nuclear type 8 A COX deficiency, benign infantile mitochondrial myopathy characterized by normal early development followed by the onset of slowly progressive decline in neurologic function in the first decade of life resulting in gait difficulties, spasticity, dysarthria, hypotonia, and variable intellectual disability that has_material_basis_in homozygous mutation in the TACO1 gene on chromosome 17q23.3. UMLS_CUI:C5436689 disease_ontology MC4DN8 MIM:619052 MIM:619052 UMLS_CUI:C5436689 DOID:0070495 COX deficiency, benign infantile mitochondrial myopathy autosomal recessive inheritance