DO_rare_slim has material basis in autosomal recessive intellectual developmental disorder neurodevelopmental disorder with poor or absent speech, dysmorphic facies, and behavioral abnormalities MIM:621182 UMLS_CUI:C6012716 UMLS_CUI:C6012716 DOID:0070815 disease_ontology An autosomal recessive intellectual developmental disorder characterized by global developmental delay including delays in walking and speech development, with some having hypotonia and inability to walk unsupported and most being nonverbal, intellectual disability ranging from mild to severe, and behavioral features including aggression, hyperactivity, and autism that has_material_basis_in homozygous mutation in the NAV3 gene on chromosome 12q21. MIM:621182 NEDSFB autosomal recessive inheritance