DO_rare_slim has material basis in Charcot-Marie-Tooth disease type 2 autosomal dominant disease Charcot-Marie-tooth disease axonal type 2FF MIM:619519 MIM:619519 UMLS_CUI:C5561981 CMT2FF disease_ontology DOID:0070836 UMLS_CUI:C5561981 A Charcot-Marie-Tooth disease type 2 characterized by early-childhood onset of difficulties walking or running due to atrophy and weakness of the lower limbs that has_material_basis_in heterozygous mutation in the CADM3 gene on chromosome 1q21. Additional symptoms include foot and ankle deformities requiring surgery or walking aids, variable distal sensory impairment, and prominent involvement of the upper limbs, with weakness and atrophy of the forearm, wrist, and intrinsic hand muscles. autosomal dominant inheritance