has material basis in autosomal dominant disease myofibrillar myopathy 6 DOID:0080097 2015-11-10T16:59:22Z disease_ontology A myofibrillar myopathy that is characterized by onset in the first decade of progressive generalized and proximal muscle weakness, respiratory insufficiency, cardiomyopathy, and skeletal deformities related to muscle weakness and that has_material_basis_in heterozygous mutation in the BAG3 gene on chromosome 10q26. BAG3-related myofibrillar myopathy MIM:612954 myofibrillar myopathy autosomal dominant inheritance