cold-induced sweating syndrome cold-induced sweating syndrome 1 DOID:0080329 disease_ontology MIM:272430 A cold-induced sweating syndrome that has_material_basis_in homozygous or compound heterozygous mutation in the CRLF1 gene on chromosome 19p13 and is characterized in the neonatal period by orofacial weakness with impaired sucking and swallowing resulting in poor feeding necessitating medical intervention.