has material basis in autosomal dominant disease developmental and epileptic encephalopathy 66 A developmental and epileptic encephalopathy characterized by onset in the first days or weeks of life of seizures, global developmental delay with hypotonia, behavioral abnormalities, and dysmorphic features or ophthalmologic defects that has_material_basis_in heterozygous mutation in the PACS2 gene on chromosome 14q32. MIM:618067 DEE66 disease_ontology DOID:0080446 early infantile epileptic encephalopathy 66 developmental and epileptic encephalopathy autosomal dominant inheritance