DO_cancer_slim NCIthesaurus derives from glial cell diffuse midline glioma, H3 K27-altered ICD10CM:C71.9 A histone mutated tumor that is characterized by loss of histone H3 p.K28me3 (K27me3) methylation and located throughout the midline structures of the central nervous system. Methylation loss may be due to p.K28M (K27M) mutation in one of the histone H3 isoforms (H3.1, H3.2, or H3.3), overexpression of EZHIP, or mutation of the EGFR gene. ORDO:723358 NCI:C185368 UMLS_CUI:C5669877 ORDO:723358 ICD10CM:C71.9 disease_ontology UMLS_CUI:C5669877 ICDO:9385/3 NCI:C185368 DOID:0080684 GARD:0026785 GARD:0026785 ICDO:9385/3 diffuse intrinsic pontine glioma diffuse midline glioma, H3 K27M-mutant histone mutated tumor