DO_rare_slim has material basis in derives from mast cell gene duplication disease hereditary alpha tryptasemia syndrome A syndrome that is characterized by high blood tryptase levels and that has_material_basis_in inherited extra copies of the alpha tryptase gene (TPSAB1), effecting multiple organ systems including skin and connective tissues, the gastrointestinal and cardiovascular systems. DOID:0080714 disease_ontology GARD:13193 syndrome gene duplication