has material basis in erythrokeratodermia variabilis autosomal dominant disease erythrokeratodermia variabilis et progressiva 6 MIM:618531 disease_ontology An erythrokeratodermia variabilis that is characterized by erythematous hyperkeratotic plaques that develop within the first year of life, beginning on distal extremities and progressing to involve the face, wrists, and ankles, with sparing of volar surfaces and that has_material_basis_in heterozygous mutation in the TRPM4 gene on chromosome 19q13. DOID:0080766 autosomal dominant inheritance