DO_rare_slim has material basis in autosomal recessive disease HMG-CoA synthase 2 deficiency 3-hydroxy-3-methylglutaryl-CoA synthase-2 deficiency GARD:2712 DOID:0081168 ORDO:35701 disease_ontology An amino acid metabolic disorder that is characterized clinically by episodes of decompensation (often associated with gastroenteritis or fasting) that present with vomiting, lethargy, hepatomegaly, non ketotic hypoglycemia and, in rare cases, coma and that has_material_basis_in mutation in the HMGCS2 gene on chromosome 1p12. MIM:605911 amino acid metabolic disorder autosomal recessive inheritance