DO_rare_slim has material basis in existence starts during autosomal recessive disease progeroid syndrome Nestor-Guillermo progeria syndrome DOID:0081334 ORDO:280576 GARD:11008 MIM:614008 disease_ontology A progeroid syndrome that is characterized by lipoatrophy, osteoporosis, and very severe osteolysis. Patients have no cardiovascular impairment, diabetes mellitus, or hypertriglyceridemia, but suffer profound skeletal abnormalities that affect their quality of life and that has_material_basis_in homozygous mutation in the BANF1 gene on chromosome 11q13. Onset is after 2 years of age. Progeria syndrome, childhood-onset, with osteolysis autosomal recessive inheritance Childhood onset