DO_rare_slim has material basis in existence starts during autosomal dominant disease distal myopathy with rimmed vacuoles A distal myopathy that is characterized by adult onset of muscle weakness affecting the distal upper and lower limbs, which may result in walking difficulties, as well as proximal weakness of the shoulder girdle muscles and that has_material_basis_in by heterozygous mutation in the SQSTM1 gene on chromosome 5q35. ORDO:602 MIM:617158 disease_ontology DOID:0081363 distal myopathy autosomal dominant inheritance Adult onset