has material basis in existence starts during autosomal dominant disease amyotrophic lateral sclerosis type 28 disease_ontology MIM:620452 DOID:0081382 An amyotrophic lateral sclerosis that is characterized by adult onset of slowly progressive limb muscle weakness and atrophy resulting in gait difficulties, loss of ambulation, and distal upper limb weakness and that has_material_basis_in a heterozygous trinucleotide repeat expansion (CGG) in the 5-prime untranslated region of the LRP12 gene on chromosome 8q22. amyotrophic lateral sclerosis autosomal dominant inheritance Adult onset trinucleotide_repeat_expansion