NCIthesaurus sickle cell disease NCI:C34676 SNOMEDCT_US_2025_09_01:35434009 ICD10CM:D57.2 MESH:D006450 DOID:0081445 ICD9CM:282.63 UMLS_CUI:C0019034 MIM:603903 A blood protein disease that is characterized by chronic hemolytic anemia and intermittent vaso-occlusive events that result in tissue ischemia leading to acute and chronic pain as well as organ damage that can affect any organ system, resulting from the replacement of one of the beta-globin subunits in hemoglobin with atypical hemoglobin molecules called hemoglobin S which can distort red blood cells into a sickle or crescent shape. Sickle cell disease subtypes should include a detailed genotypic description for the hemoglobin molecules (e.g., Hb S/S, Hb S/C, Hb S/β0-thalassemia). disease_ontology blood protein disease