has material basis in has symptom autosomal dominant disease giant axonal neuropathy 2 disease_ontology An axonal neuopathy that is characterized by distal sensory impairment, lower extremity muscle weakness and atrophy, and giant axonal swelling with neurofilament accumulation, and has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the DDB1- and CUL4-associated factor 8 (DCAF8) gene on chromosome 1q23. MIM:610100 DOID:0090069 axonal neuropathy autosomal dominant inheritance muscle weakness