DO_rare_slim aromatase excess syndrome GARD:12949 ORDO:178345 MIM:139300 A reproductive system disease characterized by increased extraglandular aromatization of steroids resulting in heterosexual precocity in males and isosexual precocity in females, and has_material_basis_in autosomal dominant inheritance of fusion of the aromatase gene (CYP19A1) with various partners, brought about by translocations and resulting in gain of function of the CYP19A1 gene. DOID:0090122 AEXS disease_ontology ICD10CM:E30.1 familial hyperestrogenism hereditary prepubertal gynecomastia increased aromatase activity reproductive system disease