has material basis in autosomal dominant nonsyndromic deafness chromosomal duplication syndrome autosomal dominant nonsyndromic deafness 51 An autosomal dominant nonsyndromic deafness that is characterized by postlingual onset in the fourth decade of life with high frequency progressive hearing loss and has_material_basis_in a 269-kb duplication of chromosome 9q21.11 involving the TJP2 and FAM189A2 genes. DFNA51 disease_ontology MIM:613558 ICD10CM:H90.3 DOID:0110577 autosomal dominant deafness 51 chromosome 9q21.11 duplication syndrome chromosome duplication