has material basis in has symptom autosomal dominant disease platelet-type bleeding disorder 12 DOID:0111058 MIM:605735 A blood platelet disease characterized by autosomal dominant inheritance of mildly increased bleeding, platelet aggregation defect, and impaired conversion of arachidonic acid to thromboxane A2 in platelets due to deficiency in PTGS1 activity. BDPLT12 PGHS1 deficiency disease_ontology platelet COX1 deficiency platelet cyclooxygenase 1 deficiency platelet prostaglandin-endoperoxide synthase 1 deficiency blood platelet disease autosomal dominant inheritance bleeding