DO_rare_slim has symptom existence starts during autosomal dominant distal hereditary motor neuronopathy autosomal dominant distal hereditary motor neuronopathy 2 DOID:0111206 disease_ontology UMLS_CUI:C3711384 MESH:C580044 DOID:0111208 MIM:158590 An autosomal dominant distal hereditary motor neuronopathy that is characterized by onset of slowly progressive distal limb weakness and atrophy with onset between 15 to 25 years of age and that has_material_basis_in heterozygous mutation in the gene encoding heat-shock 22-kD protein-8 (HSPB8) on chromosome 12q24. HMN II HMN IIA HMN2 HMN2A ORDO:139525 autosomal dominant adult spinal muscular atrophy IIA distal hereditary motor neuronopathy type 2 distal hereditary motor neuronopathy type 2A distal hereditary motor neuropathy type II distal hereditary motor neuropathy type IIA spinal Charcot-Marie-Tooth disease IIA Young adult onset muscle weakness