DO_rare_slim has material basis in has symptom autosomal recessive disease organic acidemia combined malonic and methylmalonic acidemia DOID:0111263 SNOMEDCT_US_2025_09_01:702365002 MIM:614265 disease_ontology An organic acidemia characterized by elevated levels of methylmalonic acid and malonic acid in body fluids typically resulting in developmental delay and failure to thrive in children and neurological symptoms in adults that has_material_basis_in homozygous or compound heterozygous mutation in ACSF3 on 16q24.3. UMLS_CUI:C3280314 GARD:10818 CMAMMA MESH:C580002 ORDO:289504 combined malonic and methylmalonic aciduria autosomal recessive inheritance failure to thrive