DO_rare_slim has material basis in has symptom disease has feature autosomal dominant disease dominant optic atrophy plus syndrome disease_ontology MIM:125250 A syndrome characterized by visual loss and sensorineural hearing loss with onset in childhood and associated with other symptoms including; progressive external ophthalmoplegia, muscle cramps, hyperreflexia, and ataxia that has_material_basis_in heterozygous mutation in the OPA1 gene on chromosome 3q29. DOA+ GARD:5243 SNOMEDCT_US_2025_09_01:715374003 DOID:0111340 UMLS_CUI:C3276549 optic atrophy plus syndrome optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy sensorineural hearing loss syndrome autosomal dominant inheritance ataxia hyperreflexia muscle cramp loss of vision