DO_rare_slim has material basis in has symptom existence starts during autosomal dominant disease autoimmune disease of cardiovascular system STING-associated vasculopathy with onset in infancy GARD:12357 DOID:0111457 disease_ontology ORDO:425120 An autoimmune disease of the cardiovascular system characterized by onset in infancy of autoinflammatory vasculopathy causing severe skin lesions, particularly affecting the face, ears, nose, and digits, and resulting in ulceration, eschar formation, necrosis, and, in some cases, amputation that has_material_basis_in heterozygous gain of function mutation in the TMEM173 gene on chromosome 5q31. MIM:615934 SAVI autosomal dominant inheritance Infantile onset necrosis