DO_rare_slim has material basis in disease has basis in autosomal dominant disease physical disorder congenital vertical talus MESH:D005413 MIM:192950 MEDDRA:10066242 DOID:0111568 ORDO:178382 A connective tissue disease characterized by dislocation of the talonavicular joint with vertical orientation of the talus and rigid dorsal dislocation of the navicular, equinus deformity of the calcaneus, abduction deformity of the forefoot, and contracture of the soft tissues of the hind- and mid-foot that has_material_basis_in heterozygous mutation in the HOXD10 gene on chromosome 2q31.1. disease_ontology UMLS_CUI:C0240912 CVT GARD:5488 SNOMEDCT_US_2025_09_01:205359003 congenital convex foot congenital convex pes valgus congenital rocker-bottom foot rocker-bottom foot deformity connective tissue disease autosomal dominant inheritance Abnormality of prenatal development or birth