DO_rare_slim bone development disease otopalatodigital syndrome spectrum disorder DOID:0111782 disease_ontology ORDO:364541 A bone development disease characterized by typical facial anomalies and a generalized bone dysplasia with osteodysplastic changes with skeletal dysplasia developing as varying combinations and degrees of undertubulation of the long bones, cortical irregularity and campomelia. Most but not all subtypes are associated with mutations in FLNA on chromosome Xq28. OPD spectrum disorder OPSD fronto-otopalatodigital osteodysplasia