DO_rare_slim has material basis in X-linked dominant disease otopalatodigital syndrome spectrum disorder otopalatodigital syndrome type 2 UMLS_CUI:C1844696 Andre syndrome ORDO:90652 disease_ontology GARD:5802 DOID:0111784 MESH:C538089 OPD II syndrome OPD syndrome 2 SNOMEDCT_US_2025_09_01:42432003 MIM:304120 An otopalatodigital syndrome spectrum disorder characterized by disabling skeletal anomalies and variable malformations in the hindbrain, heart, intestines, and kidneys that frequently lead to perinatal death in males and less severe phenotypes in females that has_material_basis_in hemizygous or heterozygous mutation in exons 3, 4, or 5 in males or exons 28 or 29 in females of the FLNA gene on chromosome Xq28. OPD2 faciopalatoosseous syndrome oto-palato-digital syndrome type 2 otopalatodigital syndrome type II X-linked dominant inheritance