has material basis in autosomal dominant disease thrombophilia due to activated protein C resistance disease_ontology MIM:188055 DOID:0111902 MESH:C566056 A thrombophilia characterized by resistance of F5 to cleavage and inactivation and increased tendency for thrombosis that has_material_basis_in heterozygous mutation in F5 on chromosome 1q24.2. APC resistance PCCF deficiency PROC cofactor deficiency UMLS_CUI:C1861171 THPH2 activated protein C resistance thrombophilia V thrombophilia due to deficiency of activated protein C cofactor thrombophilia autosomal dominant inheritance