NCIthesaurus has material basis in existence starts during autosomal dominant disease immunodeficiency 36 A combined T cell and B cell immunodeficiency characterized by infantile or childhood onset of recurrent bacterial respiratory tract infections, lymphoproliferation, variable antibody deficiency (sometimes with hyper IgM), chronic viral infection (EBV, CMV), and autoimmunity that has_material_basis_in heterozygous mutation in the PIK3R1 gene on chromosome 5q13. UMLS_CUI:C4014934 disease_ontology NCI:C176703 DOID:0111949 IMD36 MIM:616005 activated phosphoinositide 3-kinase delta syndrome 2 immunodeficiency-36 with lymphoproliferation combined T cell and B cell immunodeficiency autosomal dominant inheritance Infantile onset Childhood onset