DO_rare_slim has material basis in autosomal recessive disease immunodeficiency 57 DOID:0111952 IMD57 disease_ontology ORDO:529977 A primary immunodeficiency disease characterized by recurrent infections starting in the first year of life, lymphopenia, altered production of various cytokines, inflammatory polyarthritis, and chronic active inflammation of the digestive tract that has_material_basis_in homozygous or compound heterozygous mutation in the RIPK1 gene on chromosome 6p25.2. MIM:618108 immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections-lymphopenia syndrome immunodeficiency 57 with autoinflammation primary immunodeficiency disease autosomal recessive inheritance