DO_rare_slim has material basis in autosomal recessive disease immunodeficiency 35 A primary immunodeficiency disease characterized by increased susceptibility to mycobacterial infection after BCG vaccination and impaired cellular responses to IL-12, IFN-alpha/beta, IL-23, and IL-10 that has_material_basis_in homozygous or compound heterozygous mutation in the TYK2 gene on chromosome 19p13.2. disease_ontology DOID:0111989 IMD35 MESH:C566928 ORDO:331226 MIM:611521 TYK2 deficiency autosomal recessiv HIES with atypical mycobacteriosis autosomal recessive hyper-IgE syndrome with atypical mycobacteriosis susceptibility to infection due to TYK2 deficiency tyrosine kinase 2 deficiency primary immunodeficiency disease autosomal recessive inheritance