has material basis in autosomal recessive disease immunodeficiency 66 MIM:618847 DOID:0111998 IMD66 disease_ontology A primary immunodeficiency disease characterized by onset in infancy of recurrent bacterial infections and defective immune cell migration and chemotaxis primarily in neutrophils although other cell types may also be affected that has_material_basis_in homozygous or compound heterozygous mutation in the MKL1 gene on chromosome 22q13.1-q13.2. primary immunodeficiency disease autosomal recessive inheritance