has material basis in X-linked recessive disease X-Linked immunodeficiency 74 A T cell deficiency characterized by severe respiratory insufficiency in response to infection with the COVID19 coronavirus and impaired signaling through the TLR7 pathway that has_material_basis_in hemizygous mutation in the TLR7 gene on chromosome Xp22.2. DOID:0112063 IMD74 MIM:301051 TLR7 deficiency X-linked immunodeficiency 74,COVID-19-related disease_ontology respiratory insufficiency due to SARS-CoV-2 viral infection T cell deficiency X-linked recessive inheritance