DO_rare_slim has material basis in disease has basis in severe congenital neutropenia autosomal recessive disease severe congenital neutropenia 3 A severe congenital neutropenia characterized by bone marrow failure resulting in low numbers of neutrophils, increased susceptibility to bacterial and fungal infections, and increased risk of developing myelodysplastic syndrome or acute myeloid leukemia that has_material_basis_in homozygous or compound heterozygous mutation in the HAX1 gene on chromosome 1q21.3. GARD:302 Kostmann syndrome ORDO:99749 Kostmann disease disease_ontology MIM:610738 DOID:0112133 SCN3 infantile agranulocytosis autosomal recessive inheritance Abnormality of prenatal development or birth