has material basis in autosomal recessive disease developmental and epileptic encephalopathy developmental and epileptic encephalopathy 89 MIM:619124 DEE89 disease_ontology DOID:0112223 A developmental and epileptic encephalopathy characterized by onset in the first days or months of life of seizures, profound global developmental delay with impaired intellectual development, absent speech, axial hypotonia, and spastic quadriparesis that has_material_basis_in homozygous or compound heterozygous mutation in the GAD1 gene on chromosome 2q31.1. early infantile epileptic encephalopathy 89 autosomal recessive inheritance