has material basis in autosomal recessive disease nephrotic syndrome type 22 disease_ontology DOID:0112268 MIM:619155 A familial nephrotic syndrome characterized by onset of progressive kidney dysfunction in infancy, edema, hypoproteinemia, proteinuria, microscopic hematuria, effacement of the podocyte foot processes, glomerulosclerosis, and thickening of the glomerular basement membrane that has_material_basis_in homozygous or compound heterozygous mutation in the NOS1AP gene on chromosome 1q23.3. NPHS22 familial nephrotic syndrome autosomal recessive inheritance