<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/DOID?iri=http://purl.obolibrary.org/obo/DOID_12177"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:doid="http://purl.obolibrary.org/obo/doid#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/doid#DO_rare_slim">
        <rdfs:label>DO_rare_slim</rdfs:label>
    </AnnotationProperty>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/doid#NCIthesaurus">
        <rdfs:label>NCIthesaurus</rdfs:label>
    </AnnotationProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0002200 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002200">
        <rdfs:label xml:lang="en">has phenotype</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/DOID_12177 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DOID_12177">
        <rdfs:label xml:lang="en">common variable immunodeficiency</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/DOID_2583"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002200"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/HP_0004313"/>
            </Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasOBONamespace>disease_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:id>DOID:12177</oboInOwl:id>
        <oboInOwl:hasDbXref>NCI:C26725</oboInOwl:hasDbXref>
        <ns4:IAO_0000115 xml:lang="en">An agammaglobulinemia that is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells and that results in insufficient production of antibodies needed to respond to exposure of pathogens.</ns4:IAO_0000115>
        <oboInOwl:hasDbXref>SNOMEDCT_US_2025_09_01:23238000</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>UMLS_CUI:C0009447</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MIM:PS607594</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ICD10CM:D83</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym xml:lang="en">CVID</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>GARD:6140</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ICD9CM:279.06</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MESH:D017074</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ORDO:1572</oboInOwl:hasDbXref>
        <rdfs:comment xml:lang="en">Xref MGI. OMIM mapping confirmed by DO. [SN].</rdfs:comment>
        <oboInOwl:hasExactSynonym xml:lang="en">acquired agammaglobulinemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym xml:lang="en">acquired hypogammaglobulinemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym xml:lang="en">common variable agammaglobulinemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym xml:lang="en">sporadic hypogammaglobulinemia</oboInOwl:hasExactSynonym>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/doid#DO_rare_slim"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/doid#NCIthesaurus"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/DOID_2583 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/DOID_2583">
        <rdfs:label xml:lang="en">agammaglobulinemia</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/HP_0004313 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0004313">
        <rdfs:label>Decreased circulating immunoglobulin concentration</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



