DO_rare_slim NCIthesaurus Lewy body dementia disease_ontology NCI:C84826 DOID:12217 ICD9CM:331.82 GARD:3243 SNOMEDCT_US_2025_09_01:192808003 A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities that has_material_basis_in accumulation of alpha-synuclein, SCNA, (protein). The causal mutation might be in SCNA or SCNB or some other gene(s) but the end result is always accumulation of SCNA in Lewy bodies. Dementia with Lewy bodies ICD10CM:G31.83 Lewy body disease OMIM mapping confirmed by DO. [SN]. UMLS_CUI:C0752347 Diffuse Lewy body disease MESH:D020961 MIM:127750 Senile dementia of the Lewy body type dementia