DO_rare_slim NCIthesaurus Ehlers-Danlos syndrome SNOMEDCT_US_2025_09_01:268352002 GARD:6322 DOID:13359 NCI:C34568 Cutis hyperelastica UMLS_CUI:C0013720 MIM:PS130000 ICD9CM:756.83 disease_ontology DOID:14696 ICD10CM:Q79.6 A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising caused by a heritable defect in collagen synthesis, which leads to marked healing difficulties. EDS has five cardinal signs, which may be present to some degree in all of the subtypes. These five cardinal signs are skin fragility, blood vessel fragility, skin hyperelasticity, joint hypermobility, and characteristic subcutaneous nodules. MESH:D004535 OMIM mapping confirmed by DO. [LS]. OMIM mapping by NeuroDevNet. [LS]. elastic skin collagen disease