disease has feature primary angle-closure glaucoma chronic closed-angle glaucoma A primary angle-closure glaucoma characterized by chronic and progressive narrowing of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Chronic closed-angle glaucoma has_symptom progressive loss of peripheral vision, decreased vision, and occasionally headaches. Chronic closed-angle glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component. UMLS_CUI:C0154947 SNOMEDCT_US_2025_09_01:33647009 ICD9CM:365.23 ICD10CM:H40.22 disease_ontology Anatomical narrow angle glaucoma DOID:14445 chronic angle-closure glaucoma chronic narrow angle glaucoma ocular hypertension