NCIthesaurus major depressive disorder ICD9CM:296.2 DOID:2240 NCI:C195908 DOID:2241 DOID:1470 MIM:608691 ICD10CM:F32 ICD9CM:296.3 NCI:C34796 ICD10CM:F33.9 UMLS_CUI:C0154409 disease_ontology SNOMEDCT_US_2025_09_01:268621008 MIM:608516 A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality. UMLS_CUI:C0024517 DOID:7580 DOID:10614 MIM:608520 SNOMEDCT_US_2025_09_01:36923009 Xref MGI. clinical depression major depression recurrent major depression single major depressive episode unipolar depression depressive disorder