NCIthesaurus has symptom acute chest syndrome MESH:D056586 disease_ontology SNOMEDCT_US_2025_09_01:372146004 UMLS_CUI:C0742343 ICD9CM:517.3 A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph. DOID:1584 MESH:D056586 NCI:C138179 acute chest syndrome in sickle cell disease lung disease hypoxemia pleuritic chest pain tachypnea fever cough leukocytosis