DO_rare_slim NCIthesaurus has material basis in has symptom autosomal recessive disease prothrombin deficiency SNOMEDCT_US_2025_09_01:33297000 MIM:613679 A thrombophilia that is characterized by bleeding symptoms due to low levels of circulating prothrombin, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding coagulation factor II, also known as prothrombin, on chromosome 11p11. Factor II deficiency ORDO:325 disease_ontology DOID:2235 Congenital factor II deficiency MESH:C562724 Hereditary factor II deficiency disease OMIM mapping confirmed by DO. [SN]. UMLS_CUI:C0272317 NCI:C26799 hypoprothrombinemia thrombophilia autosomal recessive inheritance bleeding