DO_rare_slim NCIthesaurus gangliosidosis GM1 gangliosidosis A gangliosidosis that is characterized by progressive destruction of nerve cells in the brain and spinal cord and that has_material_basis_in mutations in the gene encoding beta-galactosidase-1 (GLB1) resulting in build up of GM1 ganglioside. NCI:C84739 DOID:3322 SNOMEDCT_US_2025_09_01:32917001 GARD:10891 ICD10CM:E75.19 Beta-galactosidase deficiency MESH:D016537 OMIM mapping confirmed by DO. [SN]. disease_ontology UMLS_CUI:C0085131 deficiency of beta-galactosidase gangliosidosis GM1