DO_cancer_slim NCIthesaurus osteosarcoma bone osteosarcoma SNOMEDCT_US_2025_09_01:307576001 NCI:C53707 UMLS_CUI:C0585442 DOID:8580 An osteosarcoma that is an usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It may arise de novo or from a pre-existing lesion of the bone. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs. DOID:3376 Osteosarcoma of bone disease_ontology primary Osteosarcoma of bone