DO_rare_slim DO_FlyBase_slim NCIthesaurus has symptom Leigh disease NCI:C84814 ORDO:506 ICD10CM:G31.82 UMLS_CUI:C0023264 A cytochrome-c oxidase deficiency disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity. Infantile necrotizing encephalomyelopathy disease_ontology MESH:D007888 GARD:6877 SNOMEDCT_US_2025_09_01:29570005 DOID:3652 Leigh syndrome MIM:256000 Xref MGI. OMIM mapping confirmed by DO. [SN]. juvenile subacute necrotizing encephalomyelopathy subacute necrotizing encephalomyelopathy cytochrome-c oxidase deficiency disease seizure loss of appetite irritability vomiting