DO_infectious_disease_slim gram-negative_bacterial_infectious_disease sexually_transmitted_infectious_disease has material basis in transmitted by primary bacterial infectious disease syphilis A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years. MESH:D002601 DOID:11095 SNOMEDCT_US_2025_09_01:736686006 disease_ontology ICD10CM:A51.0 UMLS_CUI:C0007939 DOID:4166 syphilitic chancre Treponema pallidum subsp. pallidum contact transmission vehicle-borne medical transmission placental transmission