NCIthesaurus has material basis in has major susceptibility factor autosomal dominant disease syndrome hereditary breast ovarian cancer syndrome disease_ontology BRCA1- and BRCA2-associated hereditary breast and ovarian cancer NCI:C8493 DOID:5683 UMLS_CUI:C0677776 SNOMEDCT_US_2025_09_01:718220008 A syndrome characterized by the higher than normal tendency associated with BRCA1 and BRCA2 to develop breast and ovarian cancers in genetically related families. MESH:D061325 Breast and Ovarian Cancer syndrome HBOC syndrome Hereditary Breast and Ovarian Cancer syndrome Hereditary breast and ovarian cancer Xref MGI. autosomal dominant inheritance susceptibility to familial breast-ovarian cancer 1 susceptibility to familial breast-ovarian cancer 2 susceptibility to familial breast-ovarian cancer 3 susceptibility to familial breast-ovarian cancer 4 susceptibility to familial breast-ovarian cancer 5