DO_infectious_disease_slim zoonotic_infectious_disease NCIthesaurus has major susceptibility factor human immunodeficiency virus infectious disease acquired immunodeficiency syndrome EFO:0000765 UMLS_CUI:C0001175 NCI:C2851 SNOMEDCT_US_2025_09_01:62479008 disease_ontology ICD10CM:B20 MESH:D000163 A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per microliter of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 (Lentivirus humimdef1) or Human immunodeficiency virus 2 (Lentivirus humimdef2), which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS. MESH:D000163 AIDS DOID:635 acquired Immune deficiency acquired immune deficiency syndrome susceptibility to human immunodeficiency virus type 1