DO_rare_slim NCIthesaurus hypersensitivity reaction type IV disease autoimmune lymphoproliferative syndrome UMLS_CUI:C1328840 ORDO:3261 MESH:D056735 SNOMEDCT_US_2025_09_01:702444009 A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen. disease_ontology NCI:C37864 GARD:8686 MIM:601859 ALPS DOID:6688 ICD9CM:279.41 MESH:D056735 ICD10CM:D89.82 Canale-Smith syndrome Xref MGI. OMIM mapping confirmed by DO. [SN].