DO_rare_slim NCIthesaurus has material basis in has major susceptibility factor autosomal dominant disease muscle tissue disease malignant hyperthermia MESH:D008305 disease_ontology DOID:8545 SNOMEDCT_US_2025_09_01:111738008 UMLS_CUI:C0024591 MIM:PS145600 ORDO:423 ICD10CM:T88.3 A muscle tissue disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature and that has_material_basis_in heterozygous mutation in the ryanodine receptor gene (RYR1) on chromosome 19q13. Manifestations of malignant hyperthermia (MH) are precipitated by certain volatile anesthetics (i.e., halothane, isoflurane, sevoflurane, desflurane, enflurane), either alone or in conjunction with a depolarizing muscle relaxant (specifically, succinylcholine). GARD:6964 Xref MGI. OMIM mapping confirmed by DO. [SN]. anesthesia related hyperthermia malignant hyperpyrexia due to anesthesia autosomal dominant inheritance susceptibility to malignant hyperthermia 1 susceptibility to malignant hyperthermia 5